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 Description
Application CYP3A4 inhibitor
Biochem/physiol Actions Antifungal agent
  First generation antifungal azole. Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, resulting in an altered cell membrane permeability.

Properties
assay ≥98% （TLC）
Gene Information human ... ABCB1（5243）, CYP11B1（1584）, CYP11B2（1585）, CYP17A1（1586）, CYP19A1（1588）, CYP1A2（1544）, CYP24A1（1591）, CYP26A1（1592）, CYP3A4（1576）, CYP51A1（1595）, KCNH1（3756）
  rat ... Alox5（25290）, Cyp17a1（25146）, Cyp51（25427）, Cyp7a1（25428）
  mouse ... Abcb1a（18671）, Abcb1b（18669）
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 25
Safety Statements 36-45
RIDADR UN2811 6.1/PG 3
WGK Germany 3
RTECS TK7912300